Impact of Endometriosis on Work Productivity and Quality of Life: a Survey from Italy.
Author(s)
Caserta Donatella , Bordi Giulia , Ralli Eleonora , Matteucci Eleonora , Moscarini Flaviano ,
Download Full PDF Pages: 43-49 | Views: 474 | Downloads: 113 | DOI: 10.5281/zenodo.3405972
Abstract
Endometriosis, usually called as "cancer of the career-woman", is being recognized as a “social disease” for its prevalence and its debilitating impact on young women, leading to a high socio-economic burden of the disease. This study was performed from January 2011 to January 2013 at the Department of Gynecological, Obstetrics and Urological Sciences (Sapienza University of Rome, Sant’ Andrea Hospital) in order to assess the impact of endometriosis-related symptoms on work productivity and health-related quality of life (HRQoL). Anonymous questionnaires were administered individually to a total of 254 women with surgically diagnosed endometriosis. The questionnaires consisted of three sections: Patient Health Survey (SF-12), the Endometriosis Health Profile (EHP-5), and the Work Productivity and Activity Impairment Survey (WPAI). Our results confirm that endometriosis has a significant impact on work productivity and HRQoL of affected women, leading to high economic burden and huge costs to society. Therefore it is time to make serious investments in researchers, in order to achieve a precocious diagnosis of the disease and to improve the treatment of this debilitating condition.
Keywords
Endometriosis, work productivity, quality of life, pelvic pain, women, costs
References
i. Adamson GD, Kennedy SH, Hummelshoj L. Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation. Journal of Endometriosis 2010; 2(1):3-6.
ii. Bianconi L, Hummelshoj L, Coccia ME, Vigano P, Vittori G, Veit J, et al. Recognizing endometriosis as a social disease: the European Union-encouraged Italian Senate approach. Fertililty and Sterility 2007; 88:1285–7.
iii. Bodner CH, Garratt AM, Ratcliffe J, Macdonald LM, Penney GC. Measuring health-related quality of life outcomes in women with endometriosis—results of the Gynaecology Audit Project in Scotland. Health Bullettin (Edinburgh) 1997; 55:109– 17.
iv. Damario MA, Rock JA. Pain recurrence: a quality of life issue in endometriosis. International Journal of Gynaecology and Obstetrics 1995; 50(Suppl 1):S27–42.
v. Fourquet J. Ware J Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Medical Care 1996; 34(3):220-33.
vi. Fourquet J. Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, Bullinger M, Kaasa S, Leplege A, Prieto L, Sullivan M. Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project. International Quality of Life Assessment. Journal of Clinical Epidemiology 1998; 51(11): 1171-8.
vii. Fourquet J. Wilhelm KA, Finch AW, Davenport TA, Hickie IB. What can alert the general practitioner to people whose common mental health problems are unrecognised? Medical Journal of Australia. 2008; 188(12 Suppl):S114-8.
viii. Fourquet J, Gao X, Zavala D, Orengo JC, Abac S, Ruiz A, et al. Patients’ report on how endometriosis affects health, work, and daily life. Fertility and Sterility 2010; 93:2424–8.
ix. Fourquet J, Báez L, Figueroa M, Iriarte RI, Flores I. Quantification of the impact of endometriosis symptoms on health-related quality of life and work productivity. Fertililty and Sterility 2011; 96(1):107-12.
x. Gao X, Outley J, Botteman M, Spalding J, Simon JA, Pashos CL. Economic burden of endometriosis. Fertility and Sterility 2006; 86(6):1561-72.
xi. Gao X, Yeh YC, Outley J, Simon J, Botteman M, Spalding J. Health-related quality of life burden of women with endometriosis: a literature review. Current Medical Research and Opinion 2006; 22: 1787–97.
xii. Giudice LC. Clinical practice. Endometriosis. New England Journal of Medicine. 2010; 362(25): 2389-98.
xiii. Goshtasebi A, 2011. Goshtasebi A, Nematollahzadeh M, Hariri FZ, Montazeri A. The short form endometriosis health profile (EHP-5): translation and validation study of the Iranian version. Journal of Ovarian Research 2011; 4:11.
xiv. Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Annals of Internal Medicine 1993; 118:622– 629.
xv. Jia SZ, Leng JH, Shi JH, Sun PR, Lang JH. Health-related quality of life in women with endometriosis: a systematic review. Journal of Ovarian Research 2012; 5(1):29.
xvi. Jones G, Kennedy S, Barnard A, Wong J, Jenkinson C: Development of an endometriosis quality-of-life instrument: the endometriosis health profile-30. Obstetrics and Gynecology 2001; 98: 258–264.
xvii. Jones G, Jenkinson C, Kennedy S. Evaluating the responsiveness of the endometriosis health profile questionnaire: the EHP-30. Quality of Life Research 2004; 13:705–713.
xviii. Kennedy S, Bergqvist A, Chapron C, D'Hooghe T, Dunselman G, Greb R, Hummelshoj L, Prentice A, Saridogan E. on behalf of the ESHRE Special Interest Group for Endometriosis and Endometrium Guideline Development Group. ESHRE guideline for the diagnosis and treatment of endometriosis. Human Reproduction 2005; 20:2698-2704.
xix. Lemaire GS. More than just menstrual cramps: symptoms and uncertainty among women with endometriosis. J Journal of Obstetric, Gynecologic, & Neonatal Nursing 2004; 33:71-9.
xx. Mathias SD, Castell DO, Elkin EP, Matosian ML. Health-related quality of life of patients with acute erosive reflux esophagitis. Digestive Diseases and Sciences 1996; 41:2123–9.
xxi. Nnoaham KE, Hummelshoj L, Webster P, d'Hooghe T, de Cicco Nardone F, de Cicco Nardone C, Jenkinson C, Kennedy SH, Zondervan KT; World EndometriosisResearch Foundation Global Study of Women's Health consortium. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertility and Sterility 2011; 96(2):366-373.e8.
xxii. Oehmke F, Weyand J, Hackethal A, Konrad L, Omwandho C, Tinneberg HR. Impact of endometriosis on quality of life: a pilot study. Gynecological Endocrinology 2009; 25(11):722-5.
xxiii. Reilly MC, Bracco A, Ricci JF, Santoro J, Stevens T. The validity and accuracy of the Work Productivity and Activity Impairment questionnaire-irritable bowel syndrome version (WPAI: IBS). Alimentary Pharmacology & Therapeutics 2004; 20:459– 67.
xxiv. Reilly MC, Gerlier L, Brabant Y, Brown M. Validity, reliability, and responsiveness of the work productivity and activity impairment questionnaire in Crohn’s disease. Clinical Therapeutics 2008; 30:393–404.
xxv. Reilly MC, Gooch KL, Wong RL, Kupper H, van der Heijde D. Validity, reliability and responsiveness of theWork Productivity and Activity Impairment Questionnaire in ankylosing spondylitis. Rheumatology 2010; 49:812–9.
xxvi. Simoens S, Hummelshoj L, D'Hooghe T. Endometriosis: cost estimates and methodological perspective. Human Reproduction Update 2007; 13(4):395-404.
xxvii. Simoens S, Dunselman G, Dirksen C, Hummelshoj L, Bokor A, Brandes I, Brodszky V, Canis M, Colombo GL, DeLeire T, Falcone T, Graham B, Halis G, Horne A,Kanj O, Kjer JJ, Kristensen J, Lebovic D, Mueller M, Vigano P, Wullschleger M, D'Hooghe T. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Human Reproduction 2012; 27(5): 1292-9.
xxviii. Zhao SZ, Wong JM, Davis MB, Gersh GE, Johnson KE. The cost of inpatient endometriosis treatment: an analysis based on the Healthcare Cost and Utilization Project Nationwide Inpatient Sample. The American journal of managed care 1998; 4(8):1127-34.
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